Published in: Phytotherapy Research•Year: 2018•Human Clinical Study

An overview of systematic reviews and meta-analyses of Withania somnifera

Authors: Dar PA, Singh R, Malik AH.

Journal: Phytotherapy Research, 2018

Study Background & Rationale

This overview aggregated and evaluated published systematic reviews and meta-analyses analyzing the clinical efficacy, active compounds, and safety margins of Withania somnifera.

Study DesignSystematic Review

Cohort Size12 papers

InterventionAggregate evaluation of multiple clinical cohorts taking standardized extracts across a wide age and dosing spectrum.

Key Academic Findings

01.Validated a consistent correlation between Withania somnifera and HPA-axis downregulation.
02.Indicated cognitive support and neuroprotective characteristics across preclinical and human studies.
03.Confirmed favorable safety and tolerability scores when taken in standard daily dosages.

🔬 Understanding the Evidence

Aggregated evidence supports the adaptogenic role of Ashwagandha as a stress-mitigating and cognitive-supporting compound.

Detailed Analysis

This meta-review compiles the evidence base from several clinical trials, confirming that Withania somnifera exhibits stress-mitigating properties.